The Queen of H.I.V.E. (Holistically Intergrated Viral Equality) has placed the telepathic Dr. Hector Hammond's thoughts deep into the recesses of Superman's mind in an effort to control the Man of Steel. The merging of Hammond and the Superman's minds brings about vivid hallucinations that cause Superman to experience different realities and view longtime allies as potential threats. With the Man of Steel unable to tell what is real and what is a hallucination, it is up to Orion of the New Gods and Wonder Woman to release the H.I.V.E.'s grip on Superman and save the universe from succumbing to power of the H.I.V.E.