The day after Joe and his sister Meredith board the Orient Express in Paris, they wake to find that the cabin next door has become a crime scene, and they soon find themselves caught up in an Agatha Christie-esque murder investigation. But when the steward guarding the crime scene is murdered, it marks the beginning of a killing spree which leaves five dead. Now Joe and Meredith must work to catch a cunning killer before they reach the end of the line.